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Luxury in Key West's Historic District

Make your escape to the Santa Maria Suites Hotel, an award-winning resort destination in sunny Key West. Located in the heart of the historic district, our property captures the charm and history of Key West while offering a sophisticated, fashion forward style. Well-appointed 1- and 2-bedroom suites feature luxurious furnishings, complimentary Wi-Fi and garden or pool views.


Enjoy a spacious suite with room for the whole family. Splash together in the pool, spend a day on the beach, and much more!


The romantic package at Santa Maria Suites Resort is the perfect opportunity to renew your relationship. Celebrate being together with a bottle of Champagne, and an in room couples massage!

  • Wifi
  • Restaurant Onsite
  • Pets Allowed
  • Property Size 35 units
  • Conference Facility
  • Kids Allowed
  • Nearby City Key West
  • Nearby Water Gulf of Mexico
  • Open Dates All Year

Nearest Airports

  • Key West International Airport (EYW) / 2.3 miles
  • Kawama Airport (VRO) / 103.2 miles
  • Juan Gualberto Gomez International Airport (VRA) / 107 miles

* Not all airports listed here may be open to public use, or service commercial flights

Additional Information

  • Swimming Pool
  • Beach
  • Biking/Bicycling
  • Bird Watching
  • Boating & Watercraft
  • Hiking
  • Wildlife & Nature
Room Amenities
  • Air Conditioning
  • Alarm Clock
  • Coffee Maker
  • Full Kitchen
  • In Room Safe
  • Microwave
  • Refrigerator
  • Live Entertainment
  • Photography
  • Shopping
  • Sightseeing
  • Swimming
  • ATM
  • Concierge
  • Laundry Facilities
  • Meeting Room(s)
Languages Spoken
  • English
1401 Simonton St. Key West, Florida 33040 United States  
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This property is ranked number 5 on Top 10 Key West Luxury Resorts. Read about it here.